发给老马备查:, b3 b7 U1 E( c2 A: ] `. K
滴水察海(69304838) 15:23:23
! X' X3 y7 r6 |老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
: D4 e9 c* O8 G( V7 X吉非替尼和S-1连用的依据8 b. Q. N9 {4 p: v
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
& w! e+ }8 N5 t0 Q2 |# e4 U. K; R& Y是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' x0 P; C9 a1 i% r; t这样是不是推理出,耐药后,可以用S-1和培美了?
4 |! Z" c0 W( V9 d4 I* M结论:, c# P w; e# E! ^/ g
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |