看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. $ b" d) Q7 m4 D/ B) {( R
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1 |2 n& u1 O% p( W9 ]9 {$ Q( nCombination Feasibility according to preliminary data * X0 l; N7 H* K
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% N+ a8 E$ L) h$ `* a/ ?. bBevacizumab + sorafenib Yes, reduced dose $ X' ^: @# o" K
Bevacizumab + sunitinib† No 7 w% _& Q+ b3 }5 C; m
Bevacizumab + temsirolimus Yes
8 |7 e4 }1 T$ ~0 L0 dBevacizumab + everolimus Yes
( ?' W: \3 A2 q, T; O i8 `Sorafenib + sunitinib ? : R1 p1 A: q) `7 m% s4 v; E
Sorafenib + temsirolimus Yes, reduced dose ) e- X8 S) m+ O. l" z
Sorafenib + everolimus Yes, reduced dose
, `# v* F. N8 PSunitinib + temsirolimus† No
+ N6 f9 n7 t+ i) l8 \5 ^/ gSunitinib + everolimus ?
% x' Z R- r# a% Z" ~0 ~Temsirolimus + everolimus ?
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†Led to US FDA warning.
9 J0 M# g: E9 `5 `?: As yet unattempted combination.
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